Page 7 - Journal of Structural Heart Disease - Volume 1 Issue 2

Meeting Abstracts
Journal of Structural Heart Disease, July 2015, Volume 1, Issue 2: 36-111
DOI: http://dx.doi.org/10.12945/j.jshd.2015.0004-15
Published online: July 2015
The Pediatric & Adult Interventional Cardiac Symposium (PICS/AICS)
19th Annual Meeting, Las Vegas, September 18-21, 2015
The Pediatric and Adult Interventional Cardiac Symposium – PICS-AICS 2015 is being held at the Aria Hotel, Las Vegas from September 18-21, 2015. The focus of this years meeting is on how we can overcome greater complexity through collaboration. Hence we have focused sessions outlining opportunities for greater integration with adult structural heart disease specialists and congenital surgeons. We have endeavored to ensure the meeting continues to support open dialogue as well as visual learning, along with updates from all the relevant trials and societies, with real opportunities for networking and sharing global clinical and research experience.
This year, a record number of abstracts have been submitted and a committee of experts has chosen nearly 190 abstracts for oral and poster presentations. The abstracts cover the entire gamut of interventional cardiology for congenital and structural heart disease. Two awards will be issued this year: one for the best oral abstract presenta- tion and the other one for the best poster abstract presentation.
I hope through this journal, which is the official journal of the PICS Foundation, you will be able to read through these interesting abstracts and learn more about the work our colleagues around the globe are doing in this excit- ing field. If you have any comment on any of the abstracts, feel free to communicate with the editors of the journal.
#0001
UPREGULATION OF CD40/CD40L SYSTEM IN RHEUMATIC MITRAL STENOSIS WITH OR WITHOUT ATRIAL FIBRILLATION
Nashwa Abousamra, Hanan Azzam, Mona Hafez, Abdel Hady El-Gilany, Ahmad Wafa
Faculty of Medicine, Department of Clinical Pathology, Mansoura University , Mansoura , Egypt., Mansoura, Egypt
Platelet activation occurs in peripheral blood of patients with rheu- matic mitral stenosis (MS) and atrial fibrillation (AF) and could be re- lated to abnormal thrombogenesis. The CD40/CD40 ligand (CD40L) which reflects platelet activation, mediate a central role in thrombot- ic diseases. However, the role of CD40/CD40L system in rheumatic MS with or without AF remains unclear. Expressions of CD40 on mono- cytes and CD40L on platelets were determined by whole blood flow cytometry and serum levels of soluble CD40L were measured by en- zyme-linked immunosorbent assay in group 1 (19 patients with MS) and group 2 (20 patients with MS and AF) compared to group 3 (10 controls). Patients with groups 1 and 2 had a significant increase in expression of CD40 on monocytes (P1 and P2 = 0.000) and serum lev-
els of sCD40L (P1 = 0.014 and P2 = 0.033, respectively), but nonsignif- icant increase in expression of CD40L on platelets (P1 = 0.109 and P2 = 0.060, respectively) as compared to controls. There were no signifi- cant difference in all the parameters in group 1 compared to group 2. Correlation analysis demonstrated that there was a significant direct relationship between the severity of MS and serum levels of sCD40L (r = -0.469, p = 0.043). In conclusion, rheumatic MS patients with or without AF had upregulation of the CD40/CD40L system as well as elevated sCD40L levels. The levels of sCD40L had a significantly di- rect relationship with the severity of MS and it was the stenotic mitral valve, not AF, that had a significant impact on platelet activation.
#0002
COAGULATION
POLYMORPHISM AND THE RISK OF ARTERIAL AND VENOUS THROMBOSIS
Nashwa K. Abousamra, Hanan Azzam1 Reham El-Farahaty, Hossam Elwakeel, Sherif Sakr, Eman Khashaba
Departments of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt, Mansoura, Egypt
FACTOR VII
R353Q GENE
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