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our study group in subsequent randomized trials?
• Based on the safety of PFO devices [15], is it reasonable to address a cohort with headaches less recalcitrant than migraine?
• Can we de ne a PFO or RLS headache? Are there other substrates lacking chemical conversion by the pulmonary circulation in these patients?
In conclusion, Tayaka and colleagues have deepened our knowledge base. However, investigators must ex- pand our inquiry to the basic science linking right-to-left circulation and headaches. Migraines are one of the most debilitating diseases, and, if a safe and simple car-
Letter to the Editor
diac procedure is to be provided in hopes of improving our patient’s health and quality of life in their prime, it is imperative that we cement the construct between mi- graine, RLS, and this therapy.
Con ict of Interest
The authors have no con ict of interest relevant to this publication.
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Reisman, M. et al.
Migraine and Interatrial Septal Defects
Cite this article as: Reisman M, Perpetua EM. Migraine Reduction After Transcatheter Closure of Interatrial Septal Defects: Another Brick in the Wall? Structural Heart Disease. 2016;2(5):231-233. DOI: http://dx.doi. org/10.12945/j.jshd.2016.012.15


































































































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