Page 33 - Journal of Structural Heart Disease Volume 3, Issue 3

Meeting Abstracts
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Objectives: Patients with chronic renal failure are at a higher risk of cardiac event and have poorer outcomes. Early diagnosis and treat- ment of cardiac disease are important to improve their survival. The objectives were to determine the superior cardiac marker to predict all-cause mortality at 6 years, and to determine their optimal cut o values.
Methods: A prospective observational study was carried out. Patients were included if they presented to the ED with a chief complaint of chest pain and had chronic renal failure, de ned as a serum creat- inine of more than 130 umol/L. Creatine kinase (MB), Troponin T and Troponin I (using both Abbott and DxI-Beckman assays) were performed on the blood specimens drawn. All-cause mortality was traced from review of the patients’ case records and checking of the registry of deaths.
Results: Seven hundred and fty patients were recruited with a median age of 67. 60.2% of the study population were male. 87.5% of the population had CKD stage 4 and 5, with 32.4% on dialysis. The mortality rate at 6-year was 44.8%. Signi cant predictors were age (p<0.0001), absence of hypertension (p=0.006) and history of previ- ous ischemic heart disease (p=0.025). Troponins T and I have higher AUC for all-cause mortality as compared to creatine kinase (MB). Troponin T had higher AUC when compared to troponin I by both Abbott and DxI assays. A cut-o of 0.08ug/L for troponin T had an AUC of 0.590 (sensitivity 54.8%, speci city of 58.2%, p<0.0001).
Conclusions: Troponin T is the superior cardiac marker for prognos- ticating all-cause mortality, with a higher cut-o recommended for patients with chronic renal failure, further research is necessary to examine the e ect of previously known troponin, serial troponin test- ings and utilizing troponin levels to guide therapy.
EFFICACY OF EXPANDABLE HYDROGEL POLYMER COIL EMBOLIZATION FOR AORTOPULMONARY COLLATERAL ARTERY. -EFFICACY FOR REDUCTION OF NUMBER OF COILS AND PREVENTION FOR RECANALIZATION
Tomohito Kogure, Hisashi Sugiyama, Tetsuko Ishii, Junichi Yamaguchi, In-sam park, Nobuhisa Hagiwara
Tokyo Women’s Medical University, Tokyo, Japan
Background: Aortopulmonary collateral arteries (APCA) in single ven- tricular physiology is related to plural e usion or ICU stay period after TCPC. Although coil embolization is e ective for those, it requires a large number of coils. In addition, bare platinum coil often causes recanalization.
Expandable hydrogel polymer coil (AZUR®) has unique characteristics represented by greater lling with fewer coils and is expected to pre- vent recanalization.
Objective: Reduction of the number of coils and prevention from recanalization by AZUR coil are retrospectively evaluated.
Methods: Study I: Total 11 vessels in 7 patients underwent coil embo- lization with AZUR for de novo APCAs from internal mammary artery
(IMA) (AZUR group). They were compared with age matched patients who were treated with bare platinum coil (control group).
Study II: In 2 patients, AZUR was deployed in recanalized APCAs which have been previously treated with bear platinum coils. One patient had racemose hemangioma of the bronchial artery with fatal recurrent hemoptysis.
Results: Study I: The mean age of the patients were 5.6 years (2-17) and the mean diameter of IMA was 2.5 mm (2.0-2.8 mm). The number of coils was fewer in AZUR group as compared with control group (4.3±1.8 vs 6.5±2.8, P=0.04).
Study II: Complete occlusion by AZUR was demonstrated in both patients. Recurrent hemoptysis was stopped 2 years after coil embo- lization in the child with racemose hemangioma.
Conclusion: AZUR could contribute to reduce number of coils in APCAs and also be e ective against recanalization even in Racemose hemangioma.
STRUCTURAL ACE - GENE POLYMORPHISM IN PATIENTS OF UZBEK NATIONALITY WITH DILATED CARDIOMYOPATHY
Abdullaev Timur Atanazarovich, Kurbanov Nurali Abdurakhmanovich, Tsoy Igor Arsenevich
Republican Specialized Center of Cardiology, Tashkent, Uzbekistan
Background: Dilated cardiomyopathy - a disease often genetically determined, depending on the nationality
Objective: To study the distribution of I/D polymorphism markers of ACE-genes in the Uzbek nationality with dilated cardiomyopathy (DC).
Methods: Study included 102 DC patients (39 female, 63 male), with clinical signs of II-IV FC heart failure NYHA. Duration of disease was 12.8±1.8 months. Control group included 65 healthy volunteers. All studied patients underwent clinical examination, Echocardiography, ECG, clinical-functional and laboratory methods of analysis and DNA extraction.
Results: The results obtained demonstrated prevalence of I/D gen- otype and absence of signi cant di erences in frequency alleles I and D of ACE gene in individuals of Uzbek nationality su ering from DCMP. Control group had other pattern of genotype and alleles distri- bution of polymorph marker of ACE gene: DD- genotype was veri ed in 12 (20%) patients, ID genotype – in 14 (23,3%), II-genotype – in 34 (56,7%) (P<0,01; χ2=22,2). D-allele was revealed in 41(34,2%) cases, I-allele – in 79 (65,8%) cases (p<0,001; χ2=22,8). The results obtained in healthy subjects showed signi cant accumulation of I-allele and II –genotype I/D-polymorph marker ACE gene.
Conclusion: For the rst time there was ID polymorphism of ACE gene in patients of Uzbek nationality with DC. There was shown prevalence of ID heterozygote genotype in the patients with DC and reliable prevalence of I-allele and II genotype in healthy subjects.
Journal of Structural Heart Disease, June 2017
Volume 3, Issue 3:73-95