Case Reports

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Journal of Structural Heart Disease, April 2017, Volume 3, Issue 2:43-48
DOI: 10.12945/j.jshd.2017.009.16

Successful Percutaneous Device Closure for Giant Atrial Septal Defect with Massive Pericardial Effusion and Pulmonary Hypertension in an Elderly Patient

Noriko Kikuchi, MD1, Tomohiro Sakamoto, MD1, Takashi Saito, MD1, Kazuhiro Nishigami, MD1, Teiji Akagi, MD2, Takashi Honda, MD1, Koichi Nakao, MD1

1 Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan
2 Cardiac Care Unit, Okayama University Hospital, Okayama, Japan


An 82-year-old man suffering from shortness of breath, leg edema and appetite loss visited our outpatient clinic. Although he was diagnosed with atrial septal defect (ASD) requiring surgical repair 40 years ago, he had refused an operation at that time. Echocardiography revealed a 37-mm atrial septal defect and massive pericardial effusion. Cardiac catheterization showed significant left-to-right shunt flow with Qp/Qs of 4.6 and pulmonary artery (PA) pressure of 93/35/52 mmHg. Pulmonary vascular resistance was calculated as 8.3 Wood units. Surgical treatment was no longer indicated due to his condition, and percutaneous treatment with AMPLATZER Septal Occluders (ASO) was planned instead. Diuretics, a PDE3 inhibitor, and nasal oxygen were administered preoperatively for a month. A 38-mm ASO, the maximum occluder size available in Japan, was implanted successfully. Acute decompensation did not occur after ASD closure, and his symptoms improved after ASO implantation. Cardiac catheterization on postoperative day 13 revealed no evidence of residual shunt, and his PA pressure decreased to 63/20/33 mmHg. As postoperative therapy, a PDE5 inhibitor, endothelin receptor blocker and PGI2 analog were administered for residual pulmonary hypertension. Because pericardial effusion did not disappear after pericardiocentesis, surgical pericardiostomy was performed 6 months after ASD closure, and this reduced his PA pressure to 34/16/24. Appropriate pre- and postoperative medical therapy, device closure with an ASO and pericardiostomy were effective in this frail patient, who had a giant ASD with pulmonary hypertension and massive pericardial effusion.


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Cite this article as: Kikuchi N, Sakamoto T, Saito T, Nishigami K, Akagi T, Honda T, Nakao K. Successful Percutaneous Device Closure for Giant Atrial Septal Defect with Massive Pericardial Effusion and Pulmonary Hypertension in an Elderly Patient. Structural Heart Disease 2017;3(2):43-48. DOI: 10.12945/j.jshd.2017.009.16

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